What does Nanog do? - Nature Reports Stem Cells - 0 views
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Charles Daney on 13 Sep 09In embryos and induced pluripotent stem cells, Nanog sets the ground state of pluripotency Nanog, named after the fountain of eternal youth, is considered the key to pluripotency, but its role is puzzling: it can be deleted from embryonic stem cells without causing them to differentiate, and it is not among the collection of genes that can induce specialized cells to become pluripotent. Nonetheless, it does help human cells reprogram and can be used to separate incompletely reprogrammed cells from fully reprogrammed ones.